Nutritionist and Dietist Institute of Nutrition and Food Technology University of Chile Santiago de Chile, Chile
Background: Early growth is key for short and long-term life.Infant formula with added bMFGMmay better approximate the composition of complex milk lipids in human milk and therefore, better approach human milk biological effects.
Objective: To evaluate growth through 24 months of age in infants receiving infant formula with added bMFGM until 12 months of age.
Design/Methods: In this double-blind, randomized, controlled trial infants were enrolled before 120 days of age and randomized to receive a standard cow’s milk-based infant formula (SF, n=174) or a similar formula with added whey protein-lipid concentrate (5 g/L; source of bMFGM) (EF, n=173). A reference group of infants exclusively receiving human milk was also enrolled (HM, n=235). Growth (Length-for-age [LAZ], weight-for-age [WAZ], body mass index [BMI]-for-age [BAZ] and head-circumference-for-age [HCZ] growth z-scores) through 24 months of age was the primary outcome and body composition (fat mass [FM, kg], fat-free mass [FFM, kg] and percentage body fat [%BF] using air-displacement plethysmography and deuterium dilution techniques) was a secondary outcome. Attained growth and body composition group outcomes were analysed (multiple linear regression) and longitudinal differences (EF vs SF, HM vs EF and HM vs SF) were tested (generalized estimating equations [GEE] models; p-value<0.012 considered statistically significant after Bonferroni corrections).
Results: Mean growth z-scores fell within normal range (16th-84th percentile) for all groups at all study time points. Except for a larger increase in HCZ from baseline to 6 mo (mean [95% CI]: 0.20 [0.06-0.34]; EF vs SF), no significant differences in growth z-scores (absolute or change between baseline and each study time point) were detected between formula groups (Table 1 & Figure 1). Higher z-score increases during the first 24 mo were associated with formula groups vs the HM group (p<0.012; Figure 1). Absolute FM, FFM, and %BF were also similar between SF and EF groups with the exception of higher FFM for EF vs SF at 24 mo (p=0.03; Table 1). FM and FFM changes from baseline to one and two years were higher in formula groups vs HM groups (p<0.012); no significant differences were observed in %BF trajectories between study groups. Conclusion(s): Infant formula enriched with added bovine MGFM supports normal growth through two years of age compared to standard formula.
FIGURE 1. Adjusted means (95% CI) of (A) weight-for-age (WAZ), (B) length-for-age (LAZ) and (C) body-mass-index-for-age (BAZ) z-scores at baseline, 6, 12, and 24 months of age follow-up.
TABLE 1 Anthropometric and body composition outcomes at baseline and 180, 365, and 730 days by study feeding group for the Chilean infant Nutrition randomized controlled Trial (ChiNuT)
Authors/Institutions: Angela M. Jaramillo-Ospina, University of Chile, Santiago de Chile, , Chile; Rosario Toro-Campos, University of Chile, Santiago de Chile, , Chile; Teresa Murguia-Peniche, Mead Johnson Nutritionals, Evansville, Indiana, United States; Jennifer L. Wampler, Mead Johnson Nutritionals, Evansville, Indiana, United States; Steven S. Wu, Mead Johnson Nutritionals, Evansville, Indiana, United States; Carol Lynn Berseth, Brightseed, San Francisco, California, United States; Ricardo Uauy, University of Chile, Santiago de Chile, , Chile