Well Newborn

Neonatology

Infectious Diseases

Epidemiology & Health Services Pathway

Basic Science Pathway

Cross-Disciplinary Pathway

Newborn Microbiome, Perinatal Antibiotics, and Childhood Health

Chair(s)

• 

  Heather Burris, MD, MPH

  Attending Neonatologist, Assistant Professor
  Pediatrics
  Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennyslvania
  University School of Medicine Perelman School of Medicine
  Philadelphia, Pennsylvania, United States
• 

  Sagori Mukhopadhyay, MD, MMSc

  Neonatologist
  Pediatrics
  Children's Hospital of Philadelphia, University of Philadelphia
  Philadelphia, Pennsylvania, United States

Maternal microbiota at the time of delivery has a multi-faceted role in determining the neonatal outcome: it may be a driver in the premature onset of labor, it may lead to life-threatening infection of the fetus/newborn and, in the vast majority of pregnancies, it will provide the pioneer colonizers for the newborn’s microbiome. This early microbiome plays an active part in interacting with the neonatal immune system and establishing the path for future health outcomes. While interventions that alter maternal microbiota such as perinatal antibiotics have significantly reduced adverse outcomes for mothers and neonates, this health gain has required widespread use. Half of women delivering in United States will be administered antibiotics prior to delivery either as surgical prophylaxis or for prevention of neonatal infection from pathogens such as group B streptococcus. What, if any, are the unintended consequences of interrupting the mother to child microbiota transmission? This Hot topic symposia will discuss determinants of neonatal microbiome, specifically, maternal microbiome in pregnancy and effect of perinatal antibiotics, and review the evidence for association of early life antibiotics with altered microbiota and adverse health outcomes. We will end with a discussion on emerging thoughts on alternate solutions and mitigation of potential risks

Presentations:

• 9:00 AM - 9:15 AM US CT

  Maternal microbiome: Role in neonatal health and disease
  

  Presenter: Heather H. Burris, MD, MPH – Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennyslvania
• 9:15 AM - 9:30 AM US CT

  Influencers of the neonatal microbiome
  

  Presenter: Kyle Bittinger, PhD – Children's Hospital of Philadelphia
• 9:30 AM - 9:45 AM US CT

  Why early-life antibiotics matter: The age-dependent effects of microbiome disruption
  

  Presenter: Mark Underwood, MD – University of California Davis
• 9:45 AM - 10:00 AM US CT

  Association of perinatal antibiotics and childhood outcomes
  

  Presenter: Sagori Mukhopadhyay, MD, MMSc – Children's Hospital of Philadelphia, University of Philadelphia
• 10:00 AM - 10:15 AM US CT

  Emerging concepts to mitigate altered mother-to-child microbiome transmission
  

  Presenter: Noel Mueller, MPH, PhD – Johns Hopkins University
• 10:15 AM - 10:30 AM US CT

  Perinatal Antibiotics: Where we are and where we want to be
  

  Presenter: Karen M. Puopolo, MD, PhD – Children's Hospital of Philadelphia
• 10:30 AM - 11:30 AM US CT

  Break
  

  Presenter: Belinda Thomas
• 11:30 AM - 12:00 PM US CT

  Click for Live Q&A: Newborn Microbiome, Perinatal Antibiotics, and Childhood Health
  

  Presenter: Belinda Thomas