Well Newborn
Neonatology
Infectious Diseases
Epidemiology & Health Services Pathway
Basic Science Pathway
Cross-Disciplinary Pathway
Heather Burris, MD, MPH
Attending Neonatologist, Assistant Professor
Pediatrics
Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennyslvania
University School of Medicine Perelman School of Medicine
Philadelphia, Pennsylvania, United States
Sagori Mukhopadhyay, MD, MMSc
Neonatologist
Pediatrics
Children's Hospital of Philadelphia, University of Philadelphia
Philadelphia, Pennsylvania, United States
Maternal microbiota at the time of delivery has a multi-faceted role in determining the neonatal outcome: it may be a driver in the premature onset of labor, it may lead to life-threatening infection of the fetus/newborn and, in the vast majority of pregnancies, it will provide the pioneer colonizers for the newborn’s microbiome. This early microbiome plays an active part in interacting with the neonatal immune system and establishing the path for future health outcomes. While interventions that alter maternal microbiota such as perinatal antibiotics have significantly reduced adverse outcomes for mothers and neonates, this health gain has required widespread use. Half of women delivering in United States will be administered antibiotics prior to delivery either as surgical prophylaxis or for prevention of neonatal infection from pathogens such as group B streptococcus. What, if any, are the unintended consequences of interrupting the mother to child microbiota transmission? This Hot topic symposia will discuss determinants of neonatal microbiome, specifically, maternal microbiome in pregnancy and effect of perinatal antibiotics, and review the evidence for association of early life antibiotics with altered microbiota and adverse health outcomes. We will end with a discussion on emerging thoughts on alternate solutions and mitigation of potential risks
Presenter: Heather H. Burris, MD, MPH – Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennyslvania
Presenter: Kyle Bittinger, PhD – Children's Hospital of Philadelphia
Presenter: Mark Underwood, MD – University of California Davis
Presenter: Sagori Mukhopadhyay, MD, MMSc – Children's Hospital of Philadelphia, University of Philadelphia
Presenter: Noel Mueller, MPH, PhD – Johns Hopkins University
Presenter: Karen M. Puopolo, MD, PhD – Children's Hospital of Philadelphia
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