Scholarly Sessions
Pulmonology
Neonatology
Developmental Biology
Developmental and Behavioral Pediatrics
Clinical Bioethics
Basic Science Pathway
Neurology
Critical Care
Bernard Thebaud, MD, PhD
Professor of Pediatrics
Pediatrics/Regenerative Medicine
Ottawa Hospital Research Institute
Ottawa, Ontario, Canada
While neonatal mortality has significantly decreased over the past decades, long-term morbidity following prematurity or neonatal injury remains a significant problem.
Cell-based therapies have created much excitement in neonatology based on the promise of organ regeneration. Fueled by promising preclinical studies, first early phase clinical trials have begun using a variety of cells for different indications. While mesenchymal stromal cells (MSCs) isolated from umbilical cord tissue or cord blood represent the front runner amongst cell-based therapies, the feasibility and safety of human amnion epithelial cells or cord blood derived mononuclear cells are also being explored to prevent lung and brain injury. These are early days for cell-based therapies in neonatology and much remains to be learned about the biology of repair cells, their manufacturing, safe and practical delivery and clinical trial design to optimize their efficacy.
To improve the efficacy of clinical translation of this disruptive technology, principal investigators of trials on cell-based therapies will share their experience to answer the following questions:
How to choose the optimal cell or cell-derived product?
How to monitor safety of cellular biological products in a neonatal setting?
What are the optimal outcome end-points to assess safety of cell-based interventions?
What is the optimal target population for early phase trials?
What are the regulatory requirements?
Presenter: Bernard Thebaud, MD, PhD – Ottawa Hospital Research Institute
Presenter: Maria Jesus del Cerro Marin, Associate Professor of pediatrics , Alcala de Henares University – RAMON Y CAJAL UNIVERSITY HOSPITAL- Alcalá de Henares University
Presenter: Rebecca Lim, PhD – Hudson Institute of Medical Research
Presenter: Won Soon Park, MD, PhD – Samsung Medical Center, Sungkyunkwan University School of Medicine
Presenter: Charles M. Cotten, MD MHS – Duke University
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