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Paul Winchester, MA MD
Clinical Professor of Neonatology, Director NICU
Pediatrics
Indiana University School of Medicine
Indianapolis, Indiana, United States
This video is unavailable at the request of one or more presenters.
Three generational animal models now conclusively demonstrate that fetal exposure to the same environmental chemicals now found in virtually every human pregnancy is linked to multigenerational disease. The diseases range from onset of puberty abnormalities, obesity, immune disorderes,cancer,polycystic ovaries, abormal sperm,behavioral abnormalities and perinatal complications. The mechanism of transmission of disease across generations appears to be non-genetic and correlates with epigenetic changes seen in exposed offspring and their descendants.This symposium will present the latest animal data after fetal exposure to: pesticides (DDT, premethrin,vinclozolin,atrazine, glyphosate,DEET), dioxins, jet fuel, plastics, BPA,(M Skinner), The latest data on human pesticide exposures and outcomes of pregnancy: glyphosate (P. Winchester) and long term outcomes after organophosphate exposures in pregnancy (B.Eskenazi). Diseases which have been induced in third generation descendants in rodents will be compared with human disease trends and latest funded research will be reviewed. Environmental contaminants are pervasive in pregnant women, and diseases which they cause in animals are increasing in humans. Can we begin to apply what has been learned in animals to human health (while we wait the 100 years it might take to follow a three generational human study)? Finally, we will discuss the state of governmental agencies whose mandate to protect our pregnant mothers and our children from environmental contamination. (R. Etzel).
Presenter: Paul D. Winchester, MA MD – Indiana University School of Medicine
Presenter: Michael Skinner, PhD – Washington State University
Presenter: Brenda Eskenazi, PhD – University of California Berkeley
Presenter: Ruth Etzel, MD, PhD – George Washington University
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