Scholarly Sessions
Infectious Diseases
Hospital-based Medicine
Pharmacology
Health Services Research
Cross-Disciplinary Pathway
Clinical Research Pathway
Allergy, Immunology and Rheumatology
James Antoon, MD, PhD
Assistant Professor
Pediatrics
Vanderbilt University School of Medicine
Vanderbilt University School of Medicine
Nashville, Tennessee, United States
Ten percent of the U.S. population is labeled penicillin (PCN) allergic. Recent studies have demonstrated that the majority of symptoms reported as an allergy by parents are often low-risk non-IgE mediated adverse reactions. The majority of these are cutaneous reactions that are frequently interpreted as PCN-induced but are often viral or viral-drug mediated and are not a contraindication for future PCN use. Studies have shown that the presence of a PCN allergy label results in the avoidance of the entire antibiotic class with subsequent use of broader spectrum, and more expensive suboptimal antibiotics. Appropriately de-labeling PCN allergy has been shown to improve patient safe care through antimicrobial stewardship and lowering health care costs. Recent studies have highlighted approaches for de-labeling children with PCN allergy, however rates of de-labeling remain low and a more systematic approach is needed. Furthermore, there is significant variation among institutions, clinical settings and individuals concerning which patients can be de-labeled, and how to de-label and in the different settings.
Presenter: James W. Antoon, MD, PhD – Vanderbilt University School of Medicine
Presenter: Allison Norton, MD – Vanderbilt University
Presenter: Amol Purandare, MD – Children's Mercy Hospital
Presenter: David Vyles, DO, MS – Medical College of Wisconsin
Presenter: Jennifer Goldman, MD, MSCR – Children's Mercy Hospital
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