Pulmonology
Neonatology
Developmental Biology
Children with Chronic Conditions
Basic Science Pathway
Cross-Disciplinary Pathway
Cardiology
Academic and Research Skills
Binoy Shivanna, MD, DM, PhD
Associate Professor of Pediatrics
Pediatrics
Baylor College of Medicine
Houston, Texas, United States
Karen Young, MD
Associate Professor
Pediatrics
University Of Miami Miller School Of Medicine
Miami, Florida, United States
Steven Abman, MD
Professor
Pediatrics
University of Colorado Anschutz Medical Center
Denver, Colorado, United States
Bronchopulmonary dysplasia (BPD) is a developmental lung disorder of preterm infants primarily caused by immature host defense mechanisms that prevent tissue injury and facilitate repair. This disorder is the most common complication of premature birth, and its incidence remains unchanged over the past few decades. Additionally, BPD increases long-term cardiopulmonary and neurodevelopmental morbidities of preterm infants. Pulmonary hypertension (PH) is a common morbidity of BPD. The pooled prevalence of PH in mild, moderate, and severe BPD is 6%, 12%, and 39%, respectively. Importantly, the presence of PH increases both short- and long-term morbidities and mortality in BPD infants. Further, there are no curative therapies for this disease complex. Not surprisingly, BPD is the second most expensive childhood disease after asthma. Thus, the need of the hour is to understand the pathogenic mechanisms of BPD-associated PH (BPD-PH) and develop meaningful strategies to prevent and treat this devastating disease of preterm infants. This symposium is designed to fulfill this timely need. Dr. Abman will begin the session by presenting the overview and impact of this symposium on the cardiopulmonary health of preterm infants. Dr. Shivanna will then emphasize the importance of rigor and transparency in phenotyping experimental BPD-PH, discuss the need for several models of this disease complex to avoid a “one-size-fits-all” approach, and build a case for endotype- and phenotype-targeted clinical trials. Later on, Dr. Abman, Dr. Ambalavanan, Dr. Young, Dr. Bhandari, and Dr. Wedgwood will present the new and novel pathogenic mechanisms of BPD-PH learned from the state-of-art animal studies. A primary emphasis of all the panelists will be on how this new knowledge can be translated from bench to bedside to impact the well-being of infants with this disease. Finally, the symposium participants will be allowed sufficient time to have a robust discussion with the panelists about the roadblocks to the clinical translation, directions of future research, and opportunities for collaboration.
Presenter: Steven Abman, MD – University of Colorado Anschutz Medical Center
Presenter: Binoy Shivanna, MD, DM, PhD – Baylor College of Medicine
Presenter: Steven Abman, MD – University of Colorado Anschutz Medical Center
Presenter: Namasivayam Ambalavanan, MD – University of Alabama at Birmingham
Presenter: Karen C. Young, MD – University Of Miami Miller School Of Medicine
Presenter: Vineet Bhandari, MD, DM – Children's Regional Hospital at Cooper/CMSRU
Presenter: Stephen Wedgwood, PhD – UC Davis Medical Center
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