Scholarly Sessions
Neonatology
Mental Health
Developmental Biology
Developmental and Behavioral Pediatrics
Children with Chronic Conditions
Basic Science Pathway
Neurology
Critical Care
Clinical Research Pathway
Frances Northington, MD
Professor of Pediatrics and Neurology
Pediatrics
JOHNS HOPKINS UNIVERSITY
Baltimore, Maryland, United States
Raul Chavez-Valdez, MD
Associate Professor
Pediatrics
Johns Hopkins University
Baltimore, Maryland, United States
In the years to come, many disorders of brain aging will reach epidemic proportions. Currently, there is greater appreciation of how fetal and early life exposures, lifestyles, and injuries are determinants of adult health in many domains of medicine. Astonishingly, the fields of neonatal brain injury and adult brain disease have been viewed historically as distinct non-overlapping entities, despite the existence of disorders like Down’s syndrome and leukodystrophy. Currently in neurology and neuropathology, repetitive and chronic traumatic encephalopathy and the recognition that diseases like Alzheimer’s disease and even ALS might have very long prodromal states are focusing more light on the relationships of brain events in early and later life. In this seminar we will focus on consequences of early life brain injury when superimposed on genetic predisposition to adult neurodegeneration, long term structural alterations in the brain and attention deficits as a consequence of intrauterine growth restriction, potential reprogramming of brain growth after preterm birth, and consequences of preterm birth on the cholinergic forebrain and potential mechanisms of cholinergic systems injury and recovery after neonatal hypoxia-ischemia.
Session Content
Overview: A problem without known scope Dr. Raul Chavez- Valdez
The intersection of early life brain development and injury and genetic susceptibility to adult neurodegeneration
Dr. Lee J. Martin
Does preterm birth reprogram brain growth and function: What does it mean for the future adult?
Dr. Terrie E. Inder
Brain changes in adults born preterm:The cholinergic basal forebrain
Dr. Christian Sorg
The Cholinergic system after neonatal HI; A possible new therapeutic target?
Dr. Frances J Northington
Multiple structural and functional alterations of the CNS in adults due to SGA at birth.
Dr. Gregory A. Lodygensky
Wrap up and Discussion Dr. Raul Chavez-Valdez
Adult consequences exist for every alteration or injury to the developing brain and examining multiple models of early injury and the multitude of long term consequences will reveal mechanisms that can inform recovery, appropriately timed interventions, need for lifelong monitoring of outcomes, and options for “late” therapeutics. The public health import of a link of common early life brain alterations and injuries, to later in life brain function and neurodegeneration cannot be overstated.
Presenter: Raul Chavez-Valdez, MD – Johns Hopkins University
Presenter: Lee J. Martin, PhD – Johns Hopkins University School of Medicine
Presenter: Terrie Inder, MBChB, MD – Brigham and Women's Hospital
Presenter: Christian Sorg, MD – Technical University Munich
Presenter: Frances J. Northington, MD – JOHNS HOPKINS UNIVERSITY
Presenter: Gregory Lodygensky, MD – University of Montreal
Presenter: Raul Chavez-Valdez, MD – Johns Hopkins University
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