Trainee Pathway
Scholarly Sessions
Neonatology
Neurology
Cross-Disciplinary Pathway
Clinical Research Pathway
Academic and Research Skills
Donna Ferriero, MD MS
Distinguished Professor
Pediatrics
UCSF
San Francisco, California, United States
Nathalie Maitre, MD, PhD
Professor of Pediatrics
Neonatology
Nationwide Children's Hospital
Columbus, Ohio, United States
This video is unavailable at the request of one or more presenters.
Through the topic of development of HIE therapeutics and trials, we want the audience to gain an understanding of the continuum between basic science, epidemiological, patient-oriented and clinical research, all while keeping in mind the driving reasons behind neonatal research: patient care. During decades of an incredible career, Dr. Delivoria-Papadopoulos contributed immensely to our understanding of the cellular mechanisms of cerebral injury following hypoxia. We dedicate this session to Dr. Delivoria-Papadopoulos, in recognition of her many contributions and mentoring to advance the field of basic-translational HIE research. In honor of her vision, each researcher across the continuum will show how collaboration with others has contributed to either a critical finding or overcoming a major obstacle. Dr Donna Ferriero will introduce the tribute and Dr Nathalie Maitre will moderate the Q and A session.
Presenters will explain the evolution of their science through their career, with one key finding and challenging time and the collaborations and partnerships they have leveraged along the way. The following four researchers across the continuum of career trajectories (mix of senior, mid and early career investigators) will discuss both scientific and career lessons learned from working in the field of neonatal neuroprotection.
Through the topic of development of HIE therapeutics and trials, we want the audience to gain an understanding of the continuum between basic science, epidemiological, patient-oriented and clinical research, all while keeping in mind the driving reasons behind neonatal research: patient care. During decades of an incredible career, Dr. Delivoria-Papadopoulos contributed immensely to our understanding of the cellular mechanisms of cerebral injury following hypoxia. We dedicate this session to Dr. Delivoria-Papadopoulos, in recognition of her many contributions and mentoring to advance the field of basic-translational HIE research. In honor of her vision, each researcher across the continuum will show how collaboration with others has contributed to either a critical finding or overcoming a major obstacle. Dr Donna Ferriero will introduce the tribute and Dr Nathalie Maitre (?) will moderate the Q and A session.
Presenters will explain the evolution of their science through their career, with one key finding and challenging time and the collaborations and partnerships they have leveraged along the way. The following four researchers across the continuum of career trajectories (mix of senior, mid and early career investigators) will discuss both scientific and career lessons learned from working in the field of neonatal neuroprotection.
From the first preclinical work on Erythropoietin to current large clinical trials, Dr Juul’s research trajectory gives us an overview of what it is to bring a treatment for HIE from the bench to the bedside. She will discuss a few key findings, transitions and challenges that led to large scale research on one of the first new neuroprotective agents in neonatal care.
Dr Tai Wu, an early career investigator and newly elected SPR member, will describe how MRI areas of higher brain temperature correlate with energy failure and excitotoxicity, and describe the challenges of translating fundamental in vivo findings to the bedside.
Dr. Chalak will illustrate the importance of developing novel assessments in patient-based research for HIE. She will demonstrate how an array of rigorous measurement of treatment effect, spanning serum biomarkers to a novel brain-based pattern of classification, can offer mechanistic insights to clinical HIE trials. She will talk about the challenges of using traditional clinical trials models in current HIE reserch.
Dr Yvonne Wu, a senior investigator will finish by commenting on a combined approach using clinical trials and epidemiologic studies to develop new strategies for treating and preventing HIE. She will discuss her work on developing novel strategies during labor and delivery that will better predict HIE and related birth outcomes so that treatments and biomarkers have a greater impact in the long-term.
Presenter: Donna Ferriero, MD MS – UCSF
Presenter: Sandra E. Juul, MD, PhD – University of Washington
Presenter: Tai-Wei Wu, MD – Children's Hospital Los Angeles/ Keck School of Medicine USC
Presenter: Lina Chalak, MD MSCS – UT Southwestern medical center
Presenter: Yvonne Wu, MD, MPH – UCSF
Presenter: -- --