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Discussion + Q&A ViewAttendees 255

Live Q&A for this session: Monday, May 3 11:30 am to 12:00 pm CST. Please watch the presentations in advance of this time.

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Session Type: Basic-Translational-Clinical Roundtable

Chorioamnionitis and the Neonate: A Placental Conspiracy of Silence

Monday, May 3, 2021

9:00 AM - 12:00 PM US CT

Course Number: 3200-SS-QA
Format Type: On-Demand with Live Q&A
Target Audience: Obstetricians, Neonatologists, Critical Care physicians, Pulmonologists, Infectious Disease specialists, Immunologists, Hematologists and Surgeons

Session Description:

Chair(s)

Joyce Marie Koenig, MD

Professor, Pediatrics, Molec Microbiol & Immunol
Pediatrics
Saint Louis University
Saint Louis University
Saint Louis, Missouri, United States
EM

Eleanor Molloy, MB BCh BAO PhD FRCPI

Professor
Paediatrics
Trinity College, the University of Dublin
Dublin, Ireland

Learning Objectives:

The goal of this Session is to advance understanding of fundamental concepts related to the effects of a common perinatal condition on fetal and neonatal health. To meet this, experts in the study of the placenta, epidemiology, fetal inflammation, neonatal immunology, and epidemiology will provide the audience with new information regarding the following key areas: 1. The placental diagnosis of chorioamnionitis 2. Chorioamnionitis and the placental microbiome 3. Chorioamnionitis and its effects at the maternal-fetal interface 4. Chorioamnionitis and fetal/neonatal immunity 5. Chorioamnionitis and immune priming in the neonatal gut

Chorioamnionitis is a pregnancy inflammation that is diagnosed by histologic analysis of the placenta. In its most severe form, chorioamnionitis can induce a fetal inflammatory response. It typically presents with clinical symptoms in the mother or fetus (clinical chorioamnionitis), particularly in term gestations. Conversely, histologic chorioamnionitis (HCA) is often clinically ‘silent’ and closely linked to preterm birth. HCA may contribute to the pathogenesis of neonatal complications (sepsis, brain injury, chronic lung disease, necrotizing enterocolitis). Mounting evidence also suggests that fetal exposure to inflammation could contribute to health issues in later life, including cardiovascular disease, asthma, and cognitive dysfunction. The goal of this Scientific Session is to highlight cutting-edge research focused on the pathogenesis of HCA as well as on the mechanisms that contribute to adverse fetal and neonatal outcomes. The target audience includes clinicians and scientists interested in perinatal outcomes, developmental immunology and/or mechanisms of inflammation.

Presentations:

9:00 AM - 9:05 AM US CT

Welcome
Presenter: Eleanor Molloy, MB BCh BAO PhD FRCPI – Trinity College, the University of Dublin
9:05 AM - 9:15 AM US CT

Overview
Presenter: Joyce Marie Koenig, MD – Saint Louis University
9:15 AM - 9:30 AM US CT

Histologic chorioamnionitis: implications for clinical diagnosis, treatment and prognosis
Presenter: Raymond Redline, MD – University Hospitals Cleveland Medical Center
9:30 AM - 9:45 AM US CT

Of babies & bugs: Surprising starts
Presenter: Kjersti Aagaard, MD – Baylor College of Medicine
9:45 AM - 10:00 AM US CT

Immune changes at the maternal-fetal interface during chorioamnionitis
Presenter: Suhas Kallapur, Chief of Neonatology, UCLA Mattel Children's Hosp – UCLA David Geffen School of Medicine
10:00 AM - 10:15 AM US CT

Chorioamnionitis and fetal/neonatal immunity
Presenter: Claire Chougnet, PharmD PhD – CCHMC
10:15 AM - 10:30 AM US CT

The placenta-gut connection
Presenter: Joern-Hendrik Weitkamp, MD – Vanderbilt University Medical Center
10:30 AM - 11:30 AM US CT

Break
Presenter: Belinda Thomas
11:30 AM - 12:00 PM US CT

Click for Live Q&A: Chorioamnionitis and the Neonate: A Placental Conspiracy of Silence
Presenter: Belinda Thomas